(S)-4-hydroxy-2-[7-oxo-4-(3-trifluoromethyl-phenyl)-[1,4]diazepan-1-yl]-butyric acid methyl ester → (S)-4-Oxo-2-[7-oxo-4-(3-trifluoromethyl-phenyl)-[1,4]diazepan-1-yl]-butyric acid methyl ester

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Reaction Steps

In analogy to the procedure described in example 1I, (S)-4-hydroxy-2-[7-oxo-4-(3-trifluoromethyl-phenyl)-[1,4]diazepan-1-yl]-butyric acid methyl ester gave a mixture of 4-((S)-2-oxo-tetrahydro-furan-3-yl)-1-(3-trifluoromethyl-phenyl)-[1,4]diazepan-5-one (ca 5-10%) and the title compound in 97% yield as orange oil. MS: 373.1 (MH+).

Provenance & Evidence