HRID1096208

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID66783628

未命名化合物

2 次

结构：CC(C)(C)OC(=O)CCN(CC=O)c1cccc(C(F)(F)F)c1

HCID86638382

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@@H](CCOCc1ccccc1)NCCN(CCC(=O)OC(C)(C)C)c1cccc(C(F)(F)F)c1

HCID66783358

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described in example 1E, 3-[(2-oxo-ethyl)-(3-trifluoromethyl-phenyl)-amino]-propionic acid tert-butyl ester (example 5A) and (R)-2-amino-4-benzyloxy-butyric acid methyl ester hydrochloride (intermediate 7) gave the title compound as yellow oil. MS: 539.4 (MH+).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-070d0fa802074f3192e2d8209bbef0cc
来源数据集: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08138175B2
来源说明: uspto-grants-2012_03

反应 SMILES

[C:1]([O:5][C:6](=[O:23])[CH2:7][CH2:8][N:9]([CH2:20][CH:21]=O)[C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=1)([CH3:4])([CH3:3])[CH3:2].Cl.[CH3:25][O:26][C:27](=[O:40])[C@H:28]([NH2:39])[CH2:29][CH2:30][O:31][CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>>[CH3:25][O:26][C:27](=[O:40])[C@H:28]([NH:39][CH2:21][CH2:20][N:9]([CH2:8][CH2:7][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:23])[C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=1)[CH2:29][CH2:30][O:31][CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1