HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-2-amino-4-benzyloxy-butyric acid methyl ester hydrochloride → (R)-4-Benzyloxy-2-{2-[(2-tert-butoxycarbonyl-ethyl)-(3-trifluoromethyl-phenyl)-amino]-ethylamino}-butyric acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-2-amino-4-benzyloxy-butyric acid methyl ester hydrochloride | HCID 66783628 | — |
| Reactant | 3-[(2-Oxo-ethyl)-(3-trifluoromethyl-phenyl)-amino]-propionic acid tert-butyl ester | HCID 86638382 | — |
| Product | (R)-4-Benzyloxy-2-{2-[(2-tert-butoxycarbonyl-ethyl)-(3-trifluoromethyl-phenyl)-amino]-ethylamino}-butyric acid methyl ester | HCID 66783358 | — |
Reaction Steps
In analogy to the procedure described in example 1E, 3-[(2-oxo-ethyl)-(3-trifluoromethyl-phenyl)-amino]-propionic acid tert-butyl ester (example 5A) and (R)-2-amino-4-benzyloxy-butyric acid methyl ester hydrochloride (intermediate 7) gave the title compound as yellow oil. MS: 539.4 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138175B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-070d0fa802074f3192e2d8209bbef0cc |
| Source note | uspto-grants-2012_03 |