(4S)-6-Azaspiro[2.5]octan-4-ol hydrochloride → HCID 59159315, compound

HRID 1096212Notes

Reaction equation

HRID 1096212 reaction equation
[CH3:1][O:2][C:3](=[O:27])[C@@H:4]([N:8]1[C:14](=[O:15])[CH2:13][CH2:12][N:11]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][C:23]([F:26])([F:25])[F:24])[CH:17]=2)[CH2:10][CH2:9]1)[CH2:5][CH:6]=O.Cl.[CH2:29]1[C:31]2([CH2:36][CH2:35][NH:34][CH2:33][C@H:32]2[OH:37])[CH2:30]1>>[CH3:1][O:2][C:3](=[O:27])[C@@H:4]([N:8]1[C:14](=[O:15])[CH2:13][CH2:12][N:11]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][C:23]([F:26])([F:25])[F:24])[CH:17]=2)[CH2:10][CH2:9]1)[CH2:5][CH2:6][N:34]1[CH2:35][CH2:36][C:31]2([CH2:30][CH2:29]2)[C@H:32]([OH:37])[CH2:33]1

Participants

3

Reactant 2

HCID 44541812(4S)-6-Azaspiro[2.5]octan-4-ol hydrochloride2×HCID 86638384HCID 86638384, compound

Product 1

HCID 59159315HCID 59159315, compoundYield 60%

Procedure

In analogy to the procedure described in example 1K, (S)-4-oxo-2-[7-oxo-4-(3-trifluoromethoxy-phenyl)-[1,4]diazepan-1-yl]-butyric acid methyl ester and (S)-6-aza-spiro[2.5]octan-4-ol hydrochloride (intermediate 2) gave the title compound in 60% yield as light yellow viscous oil. MS: 500.3 (MH+).

Sources & evidence

ORD record
ord-670287af028d4d718fbe34281c87dad6
Source dataset
uspto-grants-2012_03
Patent number
US08138175B2

Reaction notes

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