(4S)-6-Azaspiro[2.5]octan-4-ol hydrochloride → HCID 59159251, compound

HRID 1096217Notes

Reaction equation

HRID 1096217 reaction equation
[CH3:1][O:2][C:3](=[O:26])[C@@H:4]([N:8]1[C:14](=[O:15])[CH2:13][CH2:12][N:11]([C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)[CH2:5][CH:6]=O.Cl.[CH2:28]1[C:30]2([CH2:35][CH2:34][NH:33][CH2:32][C@H:31]2[OH:36])[CH2:29]1>>[CH3:1][O:2][C:3](=[O:26])[C@@H:4]([N:8]1[C:14](=[O:15])[CH2:13][CH2:12][N:11]([C:16]2[CH:17]=[CH:18][C:19]([C:22]([F:24])([F:23])[F:25])=[CH:20][CH:21]=2)[CH2:10][CH2:9]1)[CH2:5][CH2:6][N:33]1[CH2:34][CH2:35][C:30]2([CH2:28][CH2:29]2)[C@H:31]([OH:36])[CH2:32]1

Participants

3

Reactant 2

HCID 44541812(4S)-6-Azaspiro[2.5]octan-4-ol hydrochloride2×HCID 86638385HCID 86638385, compound

Product 1

HCID 59159251HCID 59159251, compoundYield 75%

Procedure

In analogy to the procedure described in example 1K, (S)-4-oxo-2-[7-oxo-4-(4-trifluoromethyl-phenyl)-[1,4]diazepan-1-yl]-butyric acid methyl ester and (S)-6-aza-spiro[2.5]octan-4-ol hydrochloride (intermediate 2) gave the title compound in 75% yield as light yellow foam. MS: 484.4 (MH+).

Sources & evidence

ORD record
ord-15f407ea0fb14c549bb6d0141a6e8271
Source dataset
uspto-grants-2012_03
Patent number
US08138175B2

Reaction notes

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