HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → (S)-4-Hydroxy-N,N-dimethyl-2-[7-oxo4-(3-trifluoromethyl-phenyl)-[1,4]diazepan-1-yl]-butyramide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | HCID 66783577 | HCID 66783577 | — |
| Product | (S)-4-Hydroxy-N,N-dimethyl-2-[7-oxo4-(3-trifluoromethyl-phenyl)-[1,4]diazepan-1-yl]-butyramide | HCID 66783225 | — |
Reaction Steps
In analogy to the procedure described in example 17A, 4-((S)-2-oxo-tetrahydro-furan-3-yl)-1-(3-trifluoromethyl-phenyl)-[1,4]diazepan-5-one (example 7) and dimethylamine (5.6 M in EtOH) gave the title compound in quantitative yield as an yellow oil. MS: 388.1 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138175B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-3dda1323887f483ca3a2427e8b79fe08 |
| Source note | uspto-grants-2012_03 |