(4S)-6-Azaspiro[2.5]octan-4-ol hydrochloride → HCID 45100807, compound

HRID 1096220Notes

Reaction equation

HRID 1096220 reaction equation
[CH3:1][N:2]([CH3:27])[C:3](=[O:26])[C@@H:4]([N:8]1[C:14](=[O:15])[CH2:13][CH2:12][N:11]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=2)[CH2:10][CH2:9]1)[CH2:5][CH:6]=O.Cl.[CH2:29]1[C:31]2([CH2:36][CH2:35][NH:34][CH2:33][C@H:32]2[OH:37])[CH2:30]1>>[OH:37][C@@H:32]1[CH2:33][N:34]([CH2:6][CH2:5][C@H:4]([N:8]2[C:14](=[O:15])[CH2:13][CH2:12][N:11]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:24])([F:23])[F:25])[CH:17]=3)[CH2:10][CH2:9]2)[C:3]([N:2]([CH3:1])[CH3:27])=[O:26])[CH2:35][CH2:36][C:31]21[CH2:30][CH2:29]2

Participants

3

Reactant 2

HCID 44541812(4S)-6-Azaspiro[2.5]octan-4-ol hydrochloride2×HCID 86638386HCID 86638386, compound

Product 1

HCID 45100807HCID 45100807, compoundYield 57%

Procedure

In analogy to the procedure described in example 1K, (S)—N,N-dimethyl-4-oxo-2-[7-oxo-4-(3-trifluoromethyl-phenyl)-[1,4]diazepan-1-yl]-butyramide and (S)-6-aza-spiro[2.5]octan-4-ol hydrochloride (intermediate 2) gave the title compound in 57% yield as white foam. MS: 497.3 (MH+).

Sources & evidence

ORD record
ord-f0878db2e059470db15d996936df1bfc
Source dataset
uspto-grants-2012_03
Patent number
US08138175B2

Reaction notes

Loading…