HCID 66783501, compound → HCID 59159249, compound

HRID 1096224Notes

Reaction equation

HRID 1096224 reaction equation
[CH3:1][O:2][CH2:3][C@@H:4]([N:8]1[C:14](=[O:15])[CH2:13][CH2:12][N:11]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=2)[CH2:10][CH2:9]1)[CH2:5][CH:6]=O.Cl.[CH3:27][C@@H:28]1[CH2:33][NH:32][CH2:31][C@@H:30]([OH:34])[CH2:29]1>>[OH:34][C@H:30]1[CH2:29][C@H:28]([CH3:27])[CH2:33][N:32]([CH2:6][CH2:5][C@H:4]([N:8]2[C:14](=[O:15])[CH2:13][CH2:12][N:11]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:23])[F:24])[CH:17]=3)[CH2:10][CH2:9]2)[CH2:3][O:2][CH3:1])[CH2:31]1

Participants

3

Reactant 2

HCID 66783501HCID 66783501, compound2×HCID 86638387HCID 86638387, compound

Product 1

HCID 59159249HCID 59159249, compoundYield 63%

Procedure

In analogy to the procedure described in example 1K, (S)-4-methoxy-3-[7-oxo-4-(3-trifluoromethyl-phenyl)-[1,4]diazepan-1-yl]-butyraldehyde (example 23D) and (3S,5S)-5-methyl-piperidin-3-ol hydrochloride (intermediate 4) gave the title compound in 63% yield as light yellow gum. MS: 458.3 (MH+).

Sources & evidence

ORD record
ord-0c3f3a8266a344ed82465361eb667c30
Source dataset
uspto-grants-2012_03
Patent number
US08138175B2

Reaction notes

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