4-Fluoropiperidine → 4-[3-(4-Fluoro-piperidin-1-yl)-propyl]-1-(3-trifluoromethyl-phenyl)-[1,4]diazepan-5-one

HRID 1096237Notes

Reaction equation

HRID 1096237 reaction equation
[O:1]=[C:2]1[N:8]([CH2:9][CH2:10][CH:11]=O)[CH2:7][CH2:6][N:5]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=2)[CH2:4][CH2:3]1.[F:23][CH:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>>[F:23][CH:24]1[CH2:29][CH2:28][N:27]([CH2:11][CH2:10][CH2:9][N:8]2[C:2](=[O:1])[CH2:3][CH2:4][N:5]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=3)[CH2:6][CH2:7]2)[CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 27591594-FluoropiperidineHCID 866383883-[7-Oxo-4-(3-trifluoromethyl-phenyl)-[1,4]diazepan-1-yl]-propionaldehyde

Product 1

HCID 591592954-[3-(4-Fluoro-piperidin-1-yl)-propyl]-1-(3-trifluoromethyl-phenyl)-[1,4]diazepan-5-one

Procedure

The title compound was prepared from 3-[7-oxo-4-(3-trifluoromethyl-phenyl)-[1,4]diazepan-1-yl]-propionaldehyde (Example 34C) and 4-fluoropiperidine in analogy to example 34D. MS: 402.2 (MH+).

Sources & evidence

ORD record
ord-ffba138fbbff4a5588cee504758a74e0
Source dataset
uspto-grants-2012_03
Patent number
US08138175B2

Reaction notes

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