Benzene, 1,2-dichloro-4-iodo- → 1-(3,4-Dichloro-phenyl)-4-(3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one

HRID 1096238Notes

Reaction equation

HRID 1096238 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][N:10]2[C:16](=[O:17])[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:18][C:19]1[CH:24]=[CH:23][C:22](I)=[CH:21][C:20]=1[Cl:26]>>[Cl:18][C:19]1[CH:24]=[C:23]([N:13]2[CH2:14][CH2:15][C:16](=[O:17])[N:10]([CH2:9][CH2:8][CH2:7][N:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)[CH2:11][CH2:12]2)[CH:22]=[CH:21][C:20]=1[Cl:26]

Participants

3

Reactant 2

HCID 88591Benzene, 1,2-dichloro-4-iodo-HCID 667830264-(3-Piperidin-1-yl-propyl)-[1,4]diazepan-5-one

Product 1

HCID 591592451-(3,4-Dichloro-phenyl)-4-(3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one

Procedure

The title compound was prepared from 4-(3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one (Example 33B) and 1,2-dichloro-4-iodo-benzene in analogy to example 33. MS: 384.4 (MH+, 2Cl).

Sources & evidence

ORD record
ord-346a4666b1af42bbaadd6a88ae16127f
Source dataset
uspto-grants-2012_03
Patent number
US08138175B2

Reaction notes

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