1-Iodo-3-(trifluoromethoxy)benzene → 4-(3-Piperidin-1-yl-propyl)-1-(3-trifluoromethoxy-phenyl)-[1,4]diazepan-5-one

HRID 1096239Notes

Reaction equation

HRID 1096239 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][N:10]2[C:16](=[O:17])[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.I[C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([O:25][C:26]([F:29])([F:28])[F:27])[CH:20]=1>>[N:1]1([CH2:7][CH2:8][CH2:9][N:10]2[C:16](=[O:17])[CH2:15][CH2:14][N:13]([C:23]3[CH:24]=[CH:19][CH:20]=[C:21]([O:25][C:26]([F:27])([F:28])[F:29])[CH:22]=3)[CH2:12][CH2:11]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 27772931-Iodo-3-(trifluoromethoxy)benzeneHCID 667830264-(3-Piperidin-1-yl-propyl)-[1,4]diazepan-5-one

Product 1

HCID 591592884-(3-Piperidin-1-yl-propyl)-1-(3-trifluoromethoxy-phenyl)-[1,4]diazepan-5-one

Procedure

The title compound was prepared from 4-(3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one (Example 33B) and 1-iodo-3-trifluoromethoxy-benzene in analogy to example 33. MS: 400.2 (MH+).

Sources & evidence

ORD record
ord-b79e35eedc2642f497451a397e547a2a
Source dataset
uspto-grants-2012_03
Patent number
US08138175B2

Reaction notes

Loading…