1-Iodo-3-(trifluoromethoxy)benzene → 4-[3-((S)-4-Hydroxy-6-aza-spiro[2.5]oct-6-yl)-propyl]-1-(3-trifluoromethoxy-phenyl)-[1,4]diazepan-5-one

HRID 1096243Notes

Reaction equation

HRID 1096243 reaction equation
[OH:1][C@@H:2]1[CH2:9][N:8]([CH2:10][CH2:11][CH2:12][N:13]2[C:19](=[O:20])[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[CH2:7][CH2:6][C:3]21[CH2:5][CH2:4]2.I[C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([O:28][C:29]([F:32])([F:31])[F:30])[CH:23]=1>>[OH:1][C@@H:2]1[CH2:9][N:8]([CH2:10][CH2:11][CH2:12][N:13]2[C:19](=[O:20])[CH2:18][CH2:17][N:16]([C:26]3[CH:27]=[CH:22][CH:23]=[C:24]([O:28][C:29]([F:30])([F:31])[F:32])[CH:25]=3)[CH2:15][CH2:14]2)[CH2:7][CH2:6][C:3]21[CH2:4][CH2:5]2

Participants

3

Reactant 2

HCID 27772931-Iodo-3-(trifluoromethoxy)benzeneHCID 667832354-[3-((S)-4-Hydroxy-6-aza-spiro[2.5]oct-6-yl)-propyl]-[1,4]diazepan-5-one

Product 1

HCID 591592484-[3-((S)-4-Hydroxy-6-aza-spiro[2.5]oct-6-yl)-propyl]-1-(3-trifluoromethoxy-phenyl)-[1,4]diazepan-5-one

Procedure

The title compound was prepared from 4-[3-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-propyl]-[1,4]diazepan-5-one and 1-iodo-3-trifluoromethoxy-benzene in analogy to example 33. MS: 442.3 (MH+).

Sources & evidence

ORD record
ord-d8187e7977474b4da56d404b7ce38aac
Source dataset
uspto-grants-2012_03
Patent number
US08138175B2

Reaction notes

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