HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Iodo-3-(trifluoromethoxy)benzene → 4-[3-((S)-4-Hydroxy-6-aza-spiro[2.5]oct-6-yl)-propyl]-1-(3-trifluoromethoxy-phenyl)-[1,4]diazepan-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Iodo-3-(trifluoromethoxy)benzene | HCID 2777293 | — |
| Reactant | 4-[3-((S)-4-Hydroxy-6-aza-spiro[2.5]oct-6-yl)-propyl]-[1,4]diazepan-5-one | HCID 66783235 | — |
| Product | 4-[3-((S)-4-Hydroxy-6-aza-spiro[2.5]oct-6-yl)-propyl]-1-(3-trifluoromethoxy-phenyl)-[1,4]diazepan-5-one | HCID 59159248 | — |
Reaction Steps
The title compound was prepared from 4-[3-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-propyl]-[1,4]diazepan-5-one and 1-iodo-3-trifluoromethoxy-benzene in analogy to example 33. MS: 442.3 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138175B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-d8187e7977474b4da56d404b7ce38aac |
| Source note | uspto-grants-2012_03 |