HCID 66783287, compound → HCID 66783071, compound

HRID 1096246Notes

Reaction equation

HRID 1096246 reaction equation
C(OC([N:11]1[CH2:17][CH2:16][C:15](=[O:18])[N:14]([CH2:19][CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)[CH2:13][C@H:12]1[CH3:28])=O)C1C=CC=CC=1>CO.[Pd]>[CH3:28][C@@H:12]1[CH2:13][N:14]([CH2:19][CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)[C:15](=[O:18])[CH2:16][CH2:17][NH:11]1

Participants

4

Reactant 1

HCID 66783287HCID 66783287, compound

Product 1

HCID 66783071HCID 66783071, compoundYield 83%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of (R)-2-methyl-5-oxo-4-(3-piperidin-1-yl-propyl)-[1,4]diazepane-1-carboxylic acid benzyl ester 1.0 g (3 mmol) in MeOH (20 ml) was stirred with 10% palladium on charcoal under an atmosphere of hydrogen for 1 h. Filtration and concentrated afforded the title compound 0.6 g (83%) as a colorless oil. MS: 254.2 (MH+).

Workup

  1. filtrationFiltration
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-f8f9772512124b1f9dfe774c6502e8da
Source dataset
uspto-grants-2012_03
Patent number
US08138175B2

Reaction notes

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