HCID 66783136, compound → HCID 63597022, compound

HRID 1096270Notes

Reaction equation

HRID 1096270 reaction equation
[CH3:1][CH:2]1[N:7]([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[C:10]([C:17]([F:20])([F:19])[F:18])[CH:9]=2)[CH2:6][CH2:5][NH:4][C:3]1=[O:21]>CO.[Pd]>[NH2:14][C:11]1[CH:12]=[CH:13][C:8]([N:7]2[CH2:6][CH2:5][NH:4][C:3](=[O:21])[CH:2]2[CH3:1])=[CH:9][C:10]=1[C:17]([F:20])([F:19])[F:18]

Participants

4

Reactant 1

HCID 66783136HCID 66783136, compound

Product 1

HCID 63597022HCID 63597022, compoundYield 92%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 3-methyl-4-(4-nitro-3-trifluoromethyl-phenyl)-piperazin-2-one (118 mg, 0.39 mmol) in MeOH (2 mL) was stirred at RT under a hydrogen atmosphere (1 bar) in the presence of palladium (10% on activated charcoal, 20 mg), then after 45 min insoluble material was removed by filtration through diatomaceous earth. The filtrate was evaporated to afford the title compound (98 mg, 92%). Light yellow viscous oil, MS: 274.1 (M+H)+.

Workup

  1. customafter 45 min insoluble material was removed by filtration through diatomaceous earth
  2. customThe filtrate was evaporated

Sources & evidence

ORD record
ord-e1f779caa5dc4b03993fba78043bf650
Source dataset
uspto-grants-2012_03
Patent number
US08138175B2

Reaction notes

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