3,5-Dimethylbenzenesulfonyl chloride → HCID 66786290, compound

HRID 1096499Notes

Reaction equation

HRID 1096499 reaction equation
[NH:1]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]3[CH2:10][N:11](C(OC(C)(C)C)=O)[CH2:12][CH2:13][C:3]([C:4]=23)=[CH:2]1.[CH3:21][C:22]1[CH:23]=[C:24]([S:29]([Cl:32])(=[O:31])=[O:30])[CH:25]=[C:26]([CH3:28])[CH:27]=1>>[ClH:32].[CH3:28][C:26]1[CH:25]=[C:24]([S:29]([N:1]2[C:9]3[CH:8]=[CH:7][CH:6]=[C:5]4[CH2:10][NH:11][CH2:12][CH2:13][C:3]([C:4]=34)=[CH:2]2)(=[O:30])=[O:31])[CH:23]=[C:22]([CH3:21])[CH:27]=1

Participants

3

Reactant 2

HCID 27362353,5-Dimethylbenzenesulfonyl chlorideHCID 59848834HCID 59848834, compound

Product 1

HCID 66786290HCID 66786290, compound

Procedure

The title compound was prepared from tert-butyl 1,3,4,6-tetrahydro-5H-azepino[5,4,3-cd]indole-5-carboxylate, Intermediate 12 (14 mg, 0.05 mmol) and 3,5-dimethylbenzenesulfonyl chloride (15 mg, 0.75 mmol) as described in the general procedure above, to give 8.9 mg of product. MS (ESI) m/z 341 [M+H]+.

Sources & evidence

ORD record
ord-d5e21303983b430daec204532c618978
Source dataset
uspto-grants-2012_03
Patent number
US08138333B2

Reaction notes

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