Trifluoroacetic acid → HCID 66785705, compound

HRID 1096503Notes

Reaction equation

HRID 1096503 reaction equation
[O:1]=[C:2]1[C:8]2=[CH:9][N:10]([S:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)(=[O:17])=[O:16])[C:11]3[CH:12]=[CH:13][CH:14]=[C:6]([C:7]=32)[CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.[C:31]([OH:37])([C:33]([F:36])([F:35])[F:34])=[O:32]>C(Cl)Cl>[F:34][C:33]([F:36])([F:35])[C:31]([OH:37])=[O:32].[C:18]1([S:15]([N:10]2[C:11]3[CH:12]=[CH:13][CH:14]=[C:6]4[CH2:5][NH:4][CH2:3][C:2](=[O:1])[C:8]([C:7]=34)=[CH:9]2)(=[O:17])=[O:16])[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59848832HCID 59848832, compound

Product 1

HCID 66785705HCID 66785705, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 3-oxo-1-(phenylsulfonyl)-1,3,4,6-tetrahydro-5H-azepino[5,4,3-cd]indole-5-carboxylate, Intermediate 18 (5.0 mg, 0.012 mmol) was dissolved in DCM (1 ml). TFA (0.5 ml) was added and the solution was heated to boiling. The solvent was evaporated. Obtained 5.2 mg of the TFA salt. MS (ESI+) m/z 327 [M+H]+.

Workup

  1. temperaturethe solution was heated to boiling
  2. customThe solvent was evaporated

Sources & evidence

ORD record
ord-c1712e4a552747abb3b29090fabae979
Source dataset
uspto-grants-2012_03
Patent number
US08138333B2

Reaction notes

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