反应详情

(R)-tert-Butyl 3-(7-chloro-1-(3-methoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate (0.222 mmol, 0.090 g) was added to a 10 mL round-bottomed flask equipped for stirring under nitrogen. Dichloromethane (1 mL) and trifluoroacetic acid (1 mL) were then added and the resultant solution was allowed to stir under nitrogen for 4 hr. The reaction was then concentrated and dried in-vacuo affording (R)-7-Chloro-1-(3-methoxypropyl)-2-(piperidin-3-yl)-1H-benzo[d]imidazole (30E) a brown oil and used without further purification. ESI-MS: m/z 308.2 (M+H)+.

1. customequipped
2. stirringto stir under nitrogen for 4 hr
3. concentrationThe reaction was then concentrated
4. customdried in-vacuo