反应详情

To a solution of 2-hydroxy-5-methoxybenzaldehyde (0.152 g, 1.0 mmol) in dry MeCN (50 mL) was added 4-fluorobenzyl bromide (0.145 mg, 1.0 mmol), and anhydrous K2CO3 (0.27 g, 2.0 mmol). The mixture was refluxed under stirring for 4 h, and then evaporated in vacuo. Water (100 mL) was added and the mixture was extracted with EtOAc. The separated organic layer was dried with MgSO4, and then evaporated in vacuum. Finally, the residue was eluted through a silica gel column with n-hexane/EtOAc (4:1) to give white compound I (0.21 g, 88%).

1. temperatureThe mixture was refluxed
2. customevaporated in vacuo
3. additionWater (100 mL) was added
4. extractionthe mixture was extracted with EtOAc
5. dry with materialThe separated organic layer was dried with MgSO4
6. customevaporated in vacuum
7. washFinally, the residue was eluted through a silica gel column with n-hexane/EtOAc (4:1)