反应详情

2,6-Dichloro-4-hydroxymethylphenol (3.56 g, 18.4 mmol) was dissolved in dioxane, and DDQ (4.19 g, 18.4 mmol) was added. The reaction mixture was stirred at rt overnight. The solvents were removed under reduced pressure. The residue was diluted with CH2Cl2, and the mixture was filtered. The filtrate was dried over MgSO4, filtered, and the solvents were removed under reduced pressure. Crystallization from EtOAc yielded the title compound (0.77 g, 22%). LC-MS: tR=0.82 min.

1. customThe solvents were removed under reduced pressure
2. additionThe residue was diluted with CH2Cl2
3. filtrationthe mixture was filtered
4. dry with materialThe filtrate was dried over MgSO4
5. filtrationfiltered
6. customthe solvents were removed under reduced pressure
7. customCrystallization from EtOAc