Cyclopropylamine → HCID 66783580, compound

HRID 1096835Notes

Reaction equation

HRID 1096835 reaction equation
[Cl:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=O.[CH:12]1([NH2:15])[CH2:14][CH2:13]1>>[Cl:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:3]=1[CH2:4][NH:15][CH:12]1[CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 3026202-Chloro-3-fluorobenzoic acid

Product 1

HCID 66783580HCID 66783580, compound

Procedure

Prepared from 2-chloro-3-fluorobenzoic acid (2.00 g, 11.5 mmol) and cyclopropylamine according to above-described procedures C and E, and purified over amberlyst A15 (1.86 g, 81% over 2 steps). LC-MS (2-chloro-N-cyclopropyl-3-fluorobenzamide): tR=0.76 min, ES+: 214.10; LC-MS (title compound): tR=0.60 min, ES+: 200.12.

Workup

  1. custompurified over amberlyst A15 (1.86 g, 81% over 2 steps)

Sources & evidence

ORD record
ord-855e8c4768f44a2b9b8e9f09da936a67
Source dataset
uspto-grants-2012_03
Patent number
US08138340B2

Reaction notes

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