6-[Cyclopropyl-(2,3-dichlorobenzyl)carbamoyl]-7-[4-(3-hydroxypropyl)thiazol-2-yl]-3,9-diazabicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester → 6-[Cyclopropyl-(2,3-dichlorobenzyl)carbamoyl]-7-{4-[3-(5-ethyl-4-fluoroisoxazol-3-yloxy)propyl]thiazol-2-yl}-3,9-diazabicyclo[3.3.1]-non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester
Reaktionsgleichung
[C:1]([O:5][C:6]([N:8]1[CH2:15][CH:14]2[N:16]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH:10]([CH2:11][C:12]([C:39]3[S:40][CH:41]=[C:42]([CH2:44][CH2:45][CH2:46][OH:47])[N:43]=3)=[C:13]2[C:24](=[O:38])[N:25]([CH:35]2[CH2:37][CH2:36]2)[CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([Cl:33])[C:28]=2[Cl:34])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:48]([C:50]1[O:54][N:53]=[C:52](O)[C:51]=1[F:56])[CH3:49]>>[C:1]([O:5][C:6]([N:8]1[CH2:15][CH:14]2[N:16]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH:10]([CH2:11][C:12]([C:39]3[S:40][CH:41]=[C:42]([CH2:44][CH2:45][CH2:46][O:47][C:52]4[C:51]([F:56])=[C:50]([CH2:48][CH3:49])[O:54][N:53]=4)[N:43]=3)=[C:13]2[C:24](=[O:38])[N:25]([CH:35]2[CH2:36][CH2:37]2)[CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([Cl:33])[C:28]=2[Cl:34])[CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
This compound is prepared from compound E4 and 5-ethyl-4-fluoroisoxazol-3-ol, according to the above-described procedure A. LC-MS: tR=1.24 min, ES+: 820.35.
Quellen und Nachweise
- ORD-Eintrag
- ord-875bba5973974fea98f94a30c106cb67
- Quelldatensatz
- uspto-grants-2012_03
- Patentnummer
- US08138340B2
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