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6-[Cyclopropyl-(2,3-dichlorobenzyl)carbamoyl]-7-[4-(3-hydroxypropyl)thiazol-2-yl]-3,9-diazabicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester → 6-[Cyclopropyl-(2,3-dichlorobenzyl)carbamoyl]-7-{4-[3-(5-ethyl-4-fluoroisoxazol-3-yloxy)propyl]thiazol-2-yl}-3,9-diazabicyclo[3.3.1]-non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-[Cyclopropyl-(2,3-dichlorobenzyl)carbamoyl]-7-[4-(3-hydroxypropyl)thiazol-2-yl]-3,9-diazabicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester | HCID 68570774 | — |
| 反応物 | HCID 178438224 | HCID 178438224 | — |
| 生成物 | 6-[Cyclopropyl-(2,3-dichlorobenzyl)carbamoyl]-7-{4-[3-(5-ethyl-4-fluoroisoxazol-3-yloxy)propyl]thiazol-2-yl}-3,9-diazabicyclo[3.3.1]-non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester | HCID 86637073 | — |
反応手順
This compound is prepared from compound E4 and 5-ethyl-4-fluoroisoxazol-3-ol, according to the above-described procedure A. LC-MS: tR=1.24 min, ES+: 820.35.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08138340B2 |
| 出典データセット | uspto-grants-2012_03 |
| ORD ID | ord-875bba5973974fea98f94a30c106cb67 |
| 出典メモ | uspto-grants-2012_03 |