反应详情

Et3N (38 μL), HOBT (41 mg) and WSC hydrochloride (52 mg) were added to a DMF (3 ml) solution of 3,5-diethoxy-4-(1-methyl-1H-pyrazol-4-yl)benzoic acid (65 mg), 6-(tetrazol-5-yl)spiro[chroman-2,4′-piperidin]-4-one hydrochloride (87 mg), and stirred overnight at room temperature. Water was added to the reaction liquid, the formed solid was taken out through filtration, then fully washed with water and ether. The solid was dried under reduced pressure to obtain the title compound. 1H-NMR (400 MHz, DMSO-d6) δ: 8.41 (1H, d, J=4.0 Hz), 8.23 (11, dd, J=8.0, 4.0 Hz), 8.04 (1H, s), 7.92 (1H, s), 7.32 (1H, d, J=8.0 Hz), 6.68 (2H, s), 4.32-4.18 (1H, m), 4.08 (4H, q, J=8.0 Hz), 3.86 (3H, s), 3.64-3.20 (3H, m), 2.97 (2H, s), 2.10-1.75 (4H, m), 1.37 (6H, t, J=8.0 Hz). MS [M+H]+=558.

1. filtrationthe formed solid was taken out through filtration
2. washfully washed with water and ether
3. customThe solid was dried under reduced pressure