反应详情

A solution of 5.08 g of tert-butyl 4-oxo-6-(tetrazol-5-yl)spiro[chroman-2,4′-piperidine]-1′-carboxylate (13.18 mmol), 8.8 mL of 12 M HCl (105.44 mmol) and 8 mL of methanol was heated to 50° C. until the reaction was complete. The resulting slurry was filtered, washed with 25 mL of methanol at room temperature, and dried to give 6-(tetrazol-5-yl)spiro[chroman-2,4′-piperidin]-4-one hydrochloride salt.

1. filtrationThe resulting slurry was filtered
2. washwashed with 25 mL of methanol at room temperature
3. customdried