Hydrochloric Acid → HCID 178479612, compound

HRID 1096917Notes

Reaction equation

HRID 1096917 reaction equation
[O:1]=[C:2]1[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([C:24]3[NH:28][N:27]=[N:26][N:25]=3)[CH:22]=2)[O:17][C:4]2([CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][CH2:5]2)[CH2:3]1.[ClH:29]>CO>[ClH:29].[NH:28]1[C:24]([C:21]2[CH:22]=[C:23]3[C:18](=[CH:19][CH:20]=2)[O:17][C:4]2([CH2:9][CH2:8][NH:7][CH2:6][CH2:5]2)[CH2:3][C:2]3=[O:1])=[N:25][N:26]=[N:27]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178451554HCID 178451554, compound

Product 1

HCID 178479612HCID 178479612, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 5.08 g of tert-butyl 4-oxo-6-(tetrazol-5-yl)spiro[chroman-2,4′-piperidine]-1′-carboxylate (13.18 mmol), 8.8 mL of 12 M HCl (105.44 mmol) and 8 mL of methanol was heated to 50° C. until the reaction was complete. The resulting slurry was filtered, washed with 25 mL of methanol at room temperature, and dried to give 6-(tetrazol-5-yl)spiro[chroman-2,4′-piperidin]-4-one hydrochloride salt.

Workup

  1. filtrationThe resulting slurry was filtered
  2. washwashed with 25 mL of methanol at room temperature
  3. customdried

Sources & evidence

ORD record
ord-ed75b160210e4bf98c09738b9d1a3ac7
Source dataset
uspto-grants-2012_03
Patent number
US08138197B2

Reaction notes

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