HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-(6-Oxo-1,6-dihydropyridin-3-yl)spiro[chroman-2,4'-piperidin]-4-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-Butyl 6-[6-(methoxy)pyridin-3-yl]-4-oxo-spiro[chroman-2,4'-piperidine]-1'-carboxylate | HCID 57930941 | — |
| Product | 6-(6-Oxo-1,6-dihydropyridin-3-yl)spiro[chroman-2,4'-piperidin]-4-one hydrochloride | HCID 66781806 | — |
Reaction Steps
Tert-Butyl 6-[6-(methoxy)pyridin-3-yl]-4-oxo-spiro[chroman-2,4′-piperidine]-1′-carboxylate (550 mg) was suspended in conc. HCl aq. (10 ml) and stirred at 100 deg. for 20 h. After removal of the solvent, the resulted solid was washed with MeOH and Et2O to obtain the intended compound as a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138197B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-7afb32bd2310406d95e54586a7e82680 |
| Source note | uspto-grants-2012_03 |