Hydrochloric Acid → 6-(6-Oxo-1,6-dihydropyridin-3-yl)spiro[chroman-2,4'-piperidin]-4-one hydrochloride

HRID 1096930Notes

Reaction equation

HRID 1096930 reaction equation
C[O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2[CH:10]=[C:11]3[C:28](=[CH:29][CH:30]=2)[O:27][C:14]2([CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]2)[CH2:13][C:12]3=[O:31])=[CH:5][CH:4]=1.[ClH:32]>>[ClH:32].[O:2]=[C:3]1[NH:8][CH:7]=[C:6]([C:9]2[CH:10]=[C:11]3[C:28](=[CH:29][CH:30]=2)[O:27][C:14]2([CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)[CH2:13][C:12]3=[O:31])[CH:5]=[CH:4]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 57930941Tert-Butyl 6-[6-(methoxy)pyridin-3-yl]-4-oxo-spiro[chroman-2,4'-piperidine]-1'-carboxylate

Product 1

HCID 667818066-(6-Oxo-1,6-dihydropyridin-3-yl)spiro[chroman-2,4'-piperidin]-4-one hydrochloride

Procedure

Tert-Butyl 6-[6-(methoxy)pyridin-3-yl]-4-oxo-spiro[chroman-2,4′-piperidine]-1′-carboxylate (550 mg) was suspended in conc. HCl aq. (10 ml) and stirred at 100 deg. for 20 h. After removal of the solvent, the resulted solid was washed with MeOH and Et2O to obtain the intended compound as a colorless solid.

Workup

  1. customAfter removal of the solvent
  2. washthe resulted solid was washed with MeOH and Et2O

Sources & evidence

ORD record
ord-7afb32bd2310406d95e54586a7e82680
Source dataset
uspto-grants-2012_03
Patent number
US08138197B2

Reaction notes

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