反应详情

温度

110 °C

Tert-Butyl 6-bromo-4-oxospiro[chroman-2,4′-piperidine]-1′-carboxylate (16.3 g), 5-amino-1-methyl-1H-pyrazole (4.00 g), palladium acetate (922 mg), 2-(di-t-butylphosphino)biphenyl (1.23 g) and cesium carbonate (16.1 g) were suspended in 1,4-dioxane (20 mL), and heated under reflux at 110° C. for 5 hours. The reaction liquid was filtered through Celite, the residue on the Celite was washed with chloroform, and the filtrate was concentrated under reduced pressure. The resulting residue was purified through silica gel column chromatography (hexane/EtOAc) to obtain the intended compound as a yellow amorphous solid.

1. temperatureheated
2. customThe reaction liquid
3. filtrationwas filtered through Celite
4. washthe residue on the Celite was washed with chloroform
5. concentrationthe filtrate was concentrated under reduced pressure
6. customThe resulting residue was purified through silica gel column chromatography (hexane/EtOAc)