Hydrochloric Acid → [5-(4-Oxospiro[chroman-2,4'-piperidin]-6-yl)-tetrazol-2-yl]methyl 2,2-dimethylpropanoate hydrochloride

Participants

Reaction Steps

To a solution of tert-Butyl 6-(2-{[(2,2-dimethylpropanoyl)oxy]methyl}-2H-tetrazol-5-yl)-4-oxo-spiro[chroman-2,4′-piperidine]-1′-carboxylate (68.0 g) in EtOAc (1.36 L) was added 4N HCl in EtOAc (340 ml) at 0° C. and the mixture was further stirred for 21 h at room temperature. The resulted precipitate was filtered and washed with EtOAc to give intended compound as a pale yellow solid.

Provenance & Evidence