1,4-Dioxane hydrochloride → 6-(1-Methyl-1H-pyrazol-4-yl)spiro[chroman-2,4'-piperidin]-4-one hydrochloride

HRID 1096935Notes

Reaction equation

HRID 1096935 reaction equation
[ClH:1].O1CCOCC1.[CH3:8][N:9]1[CH:13]=[C:12]([C:14]2[CH:15]=[C:16]3[C:33](=[CH:34][CH:35]=2)[O:32][C:19]2([CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20]2)[CH2:18][C:17]3=[O:36])[CH:11]=[N:10]1>CCOCC>[ClH:1].[CH3:8][N:9]1[CH:13]=[C:12]([C:14]2[CH:15]=[C:16]3[C:33](=[CH:34][CH:35]=2)[O:32][C:19]2([CH2:20][CH2:21][NH:22][CH2:23][CH2:24]2)[CH2:18][C:17]3=[O:36])[CH:11]=[N:10]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 57931011Tert-Butyl 6-(1-methyl-1H-pyrazol-4-yl)-4-oxo-spiro[chroman-2,4'-piperidine]-1'-carboxylate

Product 1

HCID 667825466-(1-Methyl-1H-pyrazol-4-yl)spiro[chroman-2,4'-piperidin]-4-one hydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

4 N hydrogen chloride/dioxane solution was added to tert-butyl 6-(1-methyl-1H-pyrazol-4-yl)-4-oxo-spiro[chroman-2,4′-piperidine]-1′-carboxylate (1.0 g), and stirred overnight at room temperature. Ether was added to the reaction liquid, the solid was taken out through filtration, washed with ether, and dried under reduced pressure to obtain the intended product as a white solid.

Workup

  1. filtrationthe solid was taken out through filtration
  2. washwashed with ether
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-17341801f03e4fbcb004b133b7fadf26
Source dataset
uspto-grants-2012_03
Patent number
US08138197B2

Reaction notes

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