1,4-Dioxane hydrochloride → 6-(1-Methyl-1H-pyrazol-4-yl)spiro[chroman-2,4'-piperidin]-4-one hydrochloride

Participants

Reaction Steps

4 N hydrogen chloride/dioxane solution was added to tert-butyl 6-(1-methyl-1H-pyrazol-4-yl)-4-oxo-spiro[chroman-2,4′-piperidine]-1′-carboxylate (1.0 g), and stirred overnight at room temperature. Ether was added to the reaction liquid, the solid was taken out through filtration, washed with ether, and dried under reduced pressure to obtain the intended product as a white solid.

Provenance & Evidence