Hydrochloric Acid → HCID 178466836, compound

Participants

Reaction Steps

Aqueous 5 N sodium hydroxide solution (0.46 mL, 2.23 mmol) was added to a THF (2.0 mL)-methanol (2.0 mL) solution of methyl 3-ethoxy-5-(tetrazol-5-yl)benzoate (190 mg, 0.77 mmol), and stirred at room temperature for 18 hours. 5 N hydrochloric acid (0.46 mL, 2.23 mmol) was added to the reaction mixture, and concentrated under reduced pressure. 20% methanol/chloroform was added to the residue, the mixture was filtered, and the filtrate was concentrated under reduced pressure to obtain the title compound as a colorless solid.

Provenance & Evidence