Hydrochloric Acid → HCID 178466836, compound

HRID 1096943Notes

Reaction equation

HRID 1096943 reaction equation
[OH-].[Na+].C1COCC1.[CH2:8]([O:10][C:11]1[CH:12]=[C:13]([CH:18]=[C:19]([C:21]2[NH:25][N:24]=[N:23][N:22]=2)[CH:20]=1)[C:14]([O:16]C)=[O:15])[CH3:9].Cl>CO>[CH2:8]([O:10][C:11]1[CH:12]=[C:13]([CH:18]=[C:19]([C:21]2[NH:25][N:24]=[N:23][N:22]=2)[CH:20]=1)[C:14]([OH:16])=[O:15])[CH3:9]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 178466837HCID 178466837, compound

Product 1

HCID 178466836HCID 178466836, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Aqueous 5 N sodium hydroxide solution (0.46 mL, 2.23 mmol) was added to a THF (2.0 mL)-methanol (2.0 mL) solution of methyl 3-ethoxy-5-(tetrazol-5-yl)benzoate (190 mg, 0.77 mmol), and stirred at room temperature for 18 hours. 5 N hydrochloric acid (0.46 mL, 2.23 mmol) was added to the reaction mixture, and concentrated under reduced pressure. 20% methanol/chloroform was added to the residue, the mixture was filtered, and the filtrate was concentrated under reduced pressure to obtain the title compound as a colorless solid.

Workup

  1. concentrationconcentrated under reduced pressure
  2. addition20% methanol/chloroform was added to the residue
  3. filtrationthe mixture was filtered
  4. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-bafbaf6ea09647bf867acc60f7ed225e
Source dataset
uspto-grants-2012_03
Patent number
US08138197B2

Reaction notes

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