HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1096952Generated: October 31, 2026
Hydrochloric Acid → Methyl 5-(tetrazol-5-yl)biphenyl-3-carboxylate
https://huagongshe.com/reaction/1096952
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Triethylamine hydrochloride | HCID 11130 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | Methyl 5-cyano-[1,1'-biphenyl]-3-carboxylate | HCID 57346364 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 5-(tetrazol-5-yl)biphenyl-3-carboxylate | HCID 178497260 | — |
Reaction Steps
Sodium azide (880 mg) and triethylamine hydrochloride (1.9 g) were added to a DMF (40 mL) solution of methyl 5-cyanobiphenyl-3-carboxylate (1.09 g), and stirred at 100° C. for 9 hours. With cooling with ice, diluted hydrochloric acid was added to it, the formed precipitate was taken out through filtration, washed with water, and dried to obtain the title compound as a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08138197B2 |
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| Source dataset | uspto-grants-2012_03 |
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| ORD ID | ord-624b9471f1da4ca598e4564e5ceafbcb |
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| Source note | uspto-grants-2012_03 |
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