反应详情

Aqueous 2 N sodium hydroxide solution (4 mL) was added to an MeOH (40 mL) solution of methyl 5-(tetrazol-5-yl)biphenyl-3-carboxylate (1.18 g), and stirred at room temperature for 45 minutes and then at 50° C. for 5 hours. Further, aqueous 2 N sodium hydroxide solution (2 mL) was added to it, and stirred at 50° C. for 2 hours. With cooling with ice, 2 N hydrochloric acid (12 mL) and water were added to it, the formed precipitate was taken out through filtration, washed with water and dried to obtain the title compound as a white powder.

1. waitat 50° C. for 5 hours
2. stirringstirred at 50° C. for 2 hours
3. additionwere added to it
4. filtrationthe formed precipitate was taken out through filtration
5. washwashed with water
6. customdried