Hydrochloric Acid → HCID 178524111, compound

HRID 1096953Notes

Reaction equation

HRID 1096953 reaction equation
[OH-].[Na+].CO.[NH:5]1[C:9]([C:10]2[CH:11]=[C:12]([C:22]([O:24]C)=[O:23])[CH:13]=[C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:15]=2)=[N:8][N:7]=[N:6]1.Cl>O>[NH:8]1[C:9]([C:10]2[CH:11]=[C:12]([C:22]([OH:24])=[O:23])[CH:13]=[C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:15]=2)=[N:5][N:6]=[N:7]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium Hydroxide2×HCID 178497260Methyl 5-(tetrazol-5-yl)biphenyl-3-carboxylate

Product 1

HCID 178524111HCID 178524111, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Aqueous 2 N sodium hydroxide solution (4 mL) was added to an MeOH (40 mL) solution of methyl 5-(tetrazol-5-yl)biphenyl-3-carboxylate (1.18 g), and stirred at room temperature for 45 minutes and then at 50° C. for 5 hours. Further, aqueous 2 N sodium hydroxide solution (2 mL) was added to it, and stirred at 50° C. for 2 hours. With cooling with ice, 2 N hydrochloric acid (12 mL) and water were added to it, the formed precipitate was taken out through filtration, washed with water and dried to obtain the title compound as a white powder.

Workup

  1. waitat 50° C. for 5 hours
  2. stirringstirred at 50° C. for 2 hours
  3. additionwere added to it
  4. filtrationthe formed precipitate was taken out through filtration
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-8bb387e1d5c3474f825cd913fe10982b
Source dataset
uspto-grants-2012_03
Patent number
US08138197B2

Reaction notes

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