Hydrochloric Acid → 2-Phenyl-6-(tetrazol-5-yl)-isonicotinic acid

HRID 1096961Notes

Reaction equation

HRID 1096961 reaction equation
[OH-].[Na+].CO.[C:5]1([C:11]2[CH:16]=[C:15]([C:17]([O:19]C)=[O:18])[CH:14]=[C:13]([C:21]3[NH:25][N:24]=[N:23][N:22]=3)[N:12]=2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.Cl>O>[C:5]1([C:11]2[CH:16]=[C:15]([C:17]([OH:19])=[O:18])[CH:14]=[C:13]([C:21]3[NH:25][N:24]=[N:23][N:22]=3)[N:12]=2)[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 178497262HCID 178497262, compound

Product 1

HCID 1785241162-Phenyl-6-(tetrazol-5-yl)-isonicotinic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

Aqueous 2 N sodium hydroxide solution (8.4 mL) was added to an MeOH (85 mL) solution of methyl 2-phenyl-6-(tetrazol-5-yl)pyridine-4-carboxylate (3.19 g), and stirred at 50° C. for 4 hours. With cooling with ice, 2N hydrochloric acid (16.8 mL) and water were added to it, the formed precipitate was taken out through filtration, washed with water and dried to obtain the title compound as a flesh-colored powder.

Workup

  1. additionwere added to it
  2. filtrationthe formed precipitate was taken out through filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-f11e60170da947568dbbb7c35cf52e6e
Source dataset
uspto-grants-2012_03
Patent number
US08138197B2

Reaction notes

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