Ethanol → HCID 66782625, compound

HRID 1096966Notes

Reaction equation

HRID 1096966 reaction equation
CCO.C([O:11][C:12]1[CH:13]=[C:14]([CH:19]=[C:20]([C:22]2[N:26]([CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:34])([CH3:33])[CH3:32])[N:25]=[N:24][N:23]=2)[CH:21]=1)[C:15]([O:17][CH3:18])=[O:16])C1C=CC=CC=1.[H][H]>[C].[Pd].C1COCC1>[OH:11][C:12]1[CH:13]=[C:14]([CH:19]=[C:20]([C:22]2[N:26]([CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:32])([CH3:34])[CH3:33])[N:25]=[N:24][N:23]=2)[CH:21]=1)[C:15]([O:17][CH3:18])=[O:16]

Participants

6

Reactant 3

HCID 702EthanolHCID 66782580HCID 66782580, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 66782625HCID 66782625, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

In a nitrogen atmosphere, 10% palladium-carbon (2.4 g) was added to an EtOH (35 mL)-THF (35 mL) mixed solution of methyl 3-benzyloxy-5-[({[2-(trimethylsilyl)ethyl]oxy}methyl)-tetrazol-5-yl]benzoate (4.02 g), and in a hydrogen atmosphere this was stirred at room temperature for 2 hours. The reaction liquid was filtered through Celite, concentrated under reduced pressure, and dried to obtain the title compound as a white powder. Not purified, this was used in the next step.

Workup

  1. customThe reaction liquid
  2. filtrationwas filtered through Celite
  3. concentrationconcentrated under reduced pressure
  4. customdried

Sources & evidence

ORD record
ord-23d957313f784863a508ba6c8c9bfbdf
Source dataset
uspto-grants-2012_03
Patent number
US08138197B2

Reaction notes

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