反应详情

温度

85 °C

Pyrrolidine (41 mg), Pd2(dba)3 (35 mg), tBu2-P-Ph-Ph (23 mg) and potassium phosphate (241 mg) were added in that order to a DME (5 mL) solution of methyl 3-{[(trifluoromethyl)-sulfonyl]oxy}-5-[({[2-(trimethylsilyl)ethyl]oxy}methyl)tetrazol-5-yl]benzoate (183 mg), and stirred at 85° C. for 4 hours. The reaction liquid was filtered through Celite, the solvent was evaporated away, the residue was diluted with ethyl acetate, water was added thereto, and the solution was extracted with ethyl acetate. The organic layer was washed with saturated saline water, dried with anhydrous sodium sulfate, filtered, and the solvent was evaporated away. The residue was purified through silica gel column chromatography (hexane/ethyl acetate) to obtain the title compound as a red oil.

1. customThe reaction liquid
2. filtrationwas filtered through Celite
3. customthe solvent was evaporated away
4. additionthe residue was diluted with ethyl acetate, water
5. additionwas added
6. extractionthe solution was extracted with ethyl acetate
7. washThe organic layer was washed with saturated saline water
8. dry with materialdried with anhydrous sodium sulfate
9. filtrationfiltered
10. customthe solvent was evaporated away
11. customThe residue was purified through silica gel column chromatography (hexane/ethyl acetate)