Trifluoroacetic acid → HCID 178497411, compound

HRID 1096968Notes

Reaction equation

HRID 1096968 reaction equation
FC(F)(F)C(O)=O.C(OC[N:12]1[C:16]([C:17]2[CH:18]=[C:19]([CH:24]=[C:25]([N:27]3[CH2:31][CH2:30][CH2:29][CH2:28]3)[CH:26]=2)[C:20]([O:22][CH3:23])=[O:21])=[N:15][N:14]=[N:13]1)C>>[N:27]1([C:25]2[CH:24]=[C:19]([CH:18]=[C:17]([C:16]3[NH:15][N:14]=[N:13][N:12]=3)[CH:26]=2)[C:20]([O:22][CH3:23])=[O:21])[CH2:28][CH2:29][CH2:30][CH2:31]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66782512Methyl 3-{[ethoxymethyl]tetrazol-5-yl}-5-pyrrolidin-1-ylbenzoate

Product 1

HCID 178497411HCID 178497411, compound

Procedure

A trifluoroacetic acid (5 mL) solution of methyl 3-{[ethoxymethyl]tetrazol-5-yl}-5-pyrrolidin-1-ylbenzoate (127 mg) was stirred at room temperature for 2 hours and then at 80° C. for 2 hours. The reaction liquid was concentrated under reduced pressure, the residue was purified through reversed-phase high-performance liquid chromatography [acetonitrile/water+0.1% trifluoroacetic acid] to obtain the title compound as a yellow powder.

Workup

  1. customThe reaction liquid
  2. concentrationwas concentrated under reduced pressure
  3. customthe residue was purified through reversed-phase high-performance liquid chromatography [acetonitrile/water+0.1% trifluoroacetic acid]

Sources & evidence

ORD record
ord-4f6b288367454e73911e1f1782e34197
Source dataset
uspto-grants-2012_03
Patent number
US08138197B2

Reaction notes

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