Potassium Carbonate → ethyl 1-cyclopropyl-4-hydroxy-1H-indole-6-carboxylate

Participants

Reaction Steps

In a 2.0-liter egg plant-type flask, potassium carbonate (69.58 g, 0.50 mol) was added to an ethanol (360 mL) solution of ethyl 4-acetoxy-1-cyclopropyl-1H-indole-6-carboxylate (72.33 g, 0.25 mol), and stirred at room temperature for 4 hours. Ethanol was removed from the reaction solution under reduced pressure, the residue was diluted with ethyl acetate, washed with water and saturated saline water, dried with sodium sulfate, and concentrated to obtain a crude product. This was crystallized with toluene and hexane to obtain the title compound as a pale brown crystal.

Provenance & Evidence