反应详情

In a 2.0-liter egg plant-type flask, potassium carbonate (69.58 g, 0.50 mol) was added to an ethanol (360 mL) solution of ethyl 4-acetoxy-1-cyclopropyl-1H-indole-6-carboxylate (72.33 g, 0.25 mol), and stirred at room temperature for 4 hours. Ethanol was removed from the reaction solution under reduced pressure, the residue was diluted with ethyl acetate, washed with water and saturated saline water, dried with sodium sulfate, and concentrated to obtain a crude product. This was crystallized with toluene and hexane to obtain the title compound as a pale brown crystal.

1. customEthanol was removed from the reaction solution under reduced pressure
2. additionthe residue was diluted with ethyl acetate
3. washwashed with water and saturated saline water
4. dry with materialdried with sodium sulfate
5. concentrationconcentrated
6. customto obtain a crude product
7. customThis was crystallized with toluene and hexane