Hydrochloric Acid → HCID 178524187, compound

HRID 1096975Notes

Reaction equation

HRID 1096975 reaction equation
[OH-].[Na+].[CH:3]1([N:6]2[C:14]3[C:9](=[C:10]([C:20]4[NH:24][N:23]=[N:22][N:21]=4)[CH:11]=[C:12]([C:15]([O:17]CC)=[O:16])[CH:13]=3)[CH:8]=[CH:7]2)[CH2:5][CH2:4]1.Cl>CO>[CH:3]1([N:6]2[C:14]3[C:9](=[C:10]([C:20]4[NH:24][N:23]=[N:22][N:21]=4)[CH:11]=[C:12]([C:15]([OH:17])=[O:16])[CH:13]=3)[CH:8]=[CH:7]2)[CH2:4][CH2:5]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178468697HCID 178468697, compound

Product 1

HCID 178524187HCID 178524187, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

In a 500-mL egg plant-type flask, aqueous 5 N sodium hydroxide solution (11 mL, 55 mmol) was added to an MeOH solution (70 mL) of ethyl 1-cyclopropyl-4-(tetrazol-5-yl)-1H-indole-6-carboxylate (5.40 g), and stirred at 60° C. for 8 hours. The reaction solution was left cooled, aqueous 5 N hydrochloric acid solution (12 mL) was added thereto, and the formed precipitate was taken out through filtration. This was washed with water and dried under reduced pressure to obtain the title compound as a colorless solid.

Workup

  1. waitThe reaction solution was left
  2. temperaturecooled
  3. filtrationthe formed precipitate was taken out through filtration
  4. washThis was washed with water
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-66f819b44f5e4f79bc8f54f28beb05e7
Source dataset
uspto-grants-2012_03
Patent number
US08138197B2

Reaction notes

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