4-Bromo-3,5-dihydroxybenzoic acid → Benzoic acid, 4-bromo-3,5-dihydroxy-, methyl ester

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Reaction Steps

In a 2.0-liter egg plant-type flask, a hydrochloric acid/methanol solution (500 mL) of 4-bromo-3,5-dihydroxybenzoic acid (50 g, 0.21 mol) was stirred with heating under reflux for 6 hours. Methanol was removed under reduced pressure to obtain a crude crystal. This was washed with hexane and chloroform to obtain the title compound as a colorless solid.

Provenance & Evidence