Ethyl Acetoacetate → HCID 178429262, compound

HRID 1096992Notes

Reaction equation

HRID 1096992 reaction equation
[NH:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1)[NH2:2].O=[C:10]([CH3:17])[CH2:11][C:12](OCC)=[O:13]>C(O)C>[CH3:17][C:10]1[CH:11]=[C:12]([OH:13])[N:1]([C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=2)[N:2]=1

Participants

4

Reactant 2

HCID 8868Ethyl AcetoacetateHCID 786452-Hydrazinopyridine

Product 1

HCID 178429262HCID 178429262, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a 1.0-liter egg plant-type flask, an ethanol solution (300 mL) of 2-hydrazinopyridine (16.3 g, 0.15 mol) and ethyl 3-oxobutanoate (20.5 g, 0.16 mol) was stirred overnight with heating under reflux. Ethanol was removed from the reaction solution under reduced pressure to obtain the title compound as a brown oily crude product.

Workup

  1. temperaturewith heating
  2. temperatureunder reflux
  3. customEthanol was removed from the reaction solution under reduced pressure

Sources & evidence

ORD record
ord-06af2ee9ee254bb6a726c2694f431b4e
Source dataset
uspto-grants-2012_03
Patent number
US08138197B2

Reaction notes

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