反应详情

In a 3.0-liter egg plant type flask, iodine (6.09 g, 24 mmol) and KOH (4.49 g, 68 mmol) were added to a DMF solution (60 mL) of ethyl 1H-indazole-6-carboxylate (4.52 g, 20 mmol), and stirred at room temperature for 2 hours. Saturated ammonium chloride water was added to it, extracted with ethyl acetate, washed with water and saturated saline water in that order, and dried with sodium sulfate. The reaction solution was filtered, concentrated, and the resulting solid was washed with a mixed solution of hexane and ethyl acetate to obtain the title compound as a yellow solid.

1. extractionextracted with ethyl acetate
2. washwashed with water and saturated saline water in that order
3. dry with materialdried with sodium sulfate
4. filtrationThe reaction solution was filtered
5. concentrationconcentrated
6. washthe resulting solid was washed with a mixed solution of hexane and ethyl acetate