Methyl chloroformate → HCID 57930984, compound

HRID 1097003Notes

Reaction equation

HRID 1097003 reaction equation
[CH3:1][O:2][C:3](Cl)=[O:4].[NH2:6][C:7]1[CH:8]=[C:9]2[C:26](=[CH:27][CH:28]=1)[O:25][C:12]1([CH2:17][CH2:16][N:15]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:14][CH2:13]1)[CH2:11][C:10]2=[O:29]>N1C=CC=CC=1>[CH3:1][O:2][C:3]([NH:6][C:7]1[CH:8]=[C:9]2[C:26](=[CH:27][CH:28]=1)[O:25][C:12]1([CH2:13][CH2:14][N:15]([C:18]([O:20][C:21]([CH3:23])([CH3:24])[CH3:22])=[O:19])[CH2:16][CH2:17]1)[CH2:11][C:10]2=[O:29])=[O:4]

Participants

4

Reactant 2

HCID 6586Methyl chloroformateHCID 66524936tert-Butyl 6-amino-4-oxo-3,4-dihydro-1'H-spiro[1-benzopyran-2,4'-piperidine]-1'-carboxylate

Product 1

HCID 57930984HCID 57930984, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Methyl chloridocarbonate was added to a solution of tert-butyl 6-amino-4-oxospiro[chroman-2,4′-piperidine]-1′-carboxylate in pyridine and stirred at room temperature for 6 hours. The solvent was removed under reduced pressure and the residue was purified by silicagel column chromatography (hexane/EtOAc) to obtain the intended compound as pale yellow foam.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe residue was purified by silicagel column chromatography (hexane/EtOAc)

Sources & evidence

ORD record
ord-a132f8438ee3452e9ea1479697362e85
Source dataset
uspto-grants-2012_03
Patent number
US08138197B2

Reaction notes

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