Sodium Hydroxide → HCID 57930912, compound

HRID 1097010Notes

Reaction equation

HRID 1097010 reaction equation
[CH:1]1([N:4]2[CH:8]=[C:7]([C:9]3[C:18]([O:19][CH2:20][CH3:21])=[CH:17][C:12]([C:13]([O:15]C)=[O:14])=[CH:11][C:10]=3[O:22][CH2:23][CH3:24])[CH:6]=[N:5]2)[CH2:3][CH2:2]1.[OH-].[Na+]>CO>[CH:1]1([N:4]2[CH:8]=[C:7]([C:9]3[C:18]([O:19][CH2:20][CH3:21])=[CH:17][C:12]([C:13]([OH:15])=[O:14])=[CH:11][C:10]=3[O:22][CH2:23][CH3:24])[CH:6]=[N:5]2)[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57930904HCID 57930904, compound

Product 1

HCID 57930912HCID 57930912, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of Methyl 4-(1-cyclopropyl-1H-pyrazol-4-yl)-3,5-diethoxybenzoate (20 mg) in MeOH (3 ml) was added aqueous 1N NaOH (240 ul) at room temperature, and the reaction mixture was stirred for over night. The mixture was concentrated under reduced pressure and aqueous 1N HCl (240 ul) was added to the residue. The mixture was concentrated under reduced pressure and dried in vacuo to give the crude title compound which was used in the next step without further purification.

Workup

  1. concentrationThe mixture was concentrated under reduced pressure and aqueous 1N HCl (240 ul)
  2. additionwas added to the residue
  3. concentrationThe mixture was concentrated under reduced pressure
  4. customdried in vacuo

Sources & evidence

ORD record
ord-a19894d213a3476abbb7802429bdba40
Source dataset
uspto-grants-2012_03
Patent number
US08138197B2

Reaction notes

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