HCID 178420353, compound → HCID 178511580, compound

HRID 1097237Notes

Reaction equation

HRID 1097237 reaction equation
C([N:8](CC1C=CC=CC=1)[C@H:9]1[CH2:14][CH2:13][C@H:12]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)[CH2:11][CH2:10]1)C1C=CC=CC=1>CO.[Pd]>[O:18]1[CH2:17][CH2:16][N:15]([C@H:12]2[CH2:11][CH2:10][C@H:9]([NH2:8])[CH2:14][CH2:13]2)[CH2:20][CH2:19]1

Participants

4

Reactant 1

HCID 178420353HCID 178420353, compound

Product 1

HCID 178511580HCID 178511580, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

7.2 g (16.4 mmol) of trans-dibenzyl-4-morpholino-cyclohexylamine are dissolved in 100 mL of MeOH and hydrogenated on 1.4 g of Pd/C (10%) at 30-50° C. The solvent is eliminated in vacuo and the residue is crystallised from ethanol and concentrated HCl.

Workup

  1. customthe residue is crystallised from ethanol and concentrated HCl

Sources & evidence

ORD record
ord-ebc29fad280c407d8638f9ce4b4345c7
Source dataset
uspto-grants-2012_03
Patent number
US08143247B2

Reaction notes

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