HRID1097241

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：c1ccc(CN(Cc2ccccc2)[C@H]2CC[C@@H](N3CCN(CC4CC4)CC3)CC2)cc1

HCID178420351

未命名化合物

PRODUCTS

产物

反应SMILES：N[C@H]1CC[C@@H](N2CCN(CC3CC3)CC2)CC1

HCID178511578

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

8.5 g (20 mmol) of cis-dibenzyl-[4-(4-cyclopropylmethyl-piperazin-1-yl)-cyclohexyl]-amine are dissolved in 170 mL MeOH and hydrogenated on 1.7 g Pd/C (10%) at 30-50° C. The solvent is eliminated in vacuo and the residue is crystallised from ethanol and concentrated HCl. Yield: 4.4 g (91%).

WORKUP

后处理

customthe residue is crystallised from ethanol and concentrated HCl