HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 178420351, compound → HCID 178511578, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 178420351 | HCID 178420351 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178511578 | HCID 178511578 | — |
Reaction Steps
8.5 g (20 mmol) of cis-dibenzyl-[4-(4-cyclopropylmethyl-piperazin-1-yl)-cyclohexyl]-amine are dissolved in 170 mL MeOH and hydrogenated on 1.7 g Pd/C (10%) at 30-50° C. The solvent is eliminated in vacuo and the residue is crystallised from ethanol and concentrated HCl. Yield: 4.4 g (91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08143247B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-42cd7e5eedd94278917a0a2dd4d525e7 |
| Source note | uspto-grants-2012_03 |